Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMOArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral drugs atomic binding blind cascade cellular Clustering complex cytotoxicity docking evaluated exhibited flexible FMO inhibitor interact Interaction Ligand M pro mechanism molecular Pathways protease protein-ligand interactions provided residues SARS-CoV-2 SARS-CoV-2 main protease target protein the binding affinity the SARS-CoV-2 [DOI] 10.1038/s41598-022-22703-1 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Cov2clusters: genomic clustering of SARS-CoV-2 sequencesArticle Published on 2022-10-192022-11-16 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Accuracy advance approach bioinformatics Canada Cluster Clustering Combination COVID-19 pandemic epidemiological data epidemiologically Evidence genomic Genomic analysis global public health high accuracy High-resolution identify identifying increase in management mimicking pandemic pathogen Phylogenetic Phylogenetic tree produced producing Public public health Repository SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequence data sequence sequencing technology stability Surveillance the disease Transmission viral pathogen WGS whole genome sequence Whole genome sequencing whole genome sequencing. [DOI] 10.1186/s12864-022-08936-4 PMC 바로가기
Revealing Public Opinion towards the COVID-19 Vaccine with Weibo Data in China: BertFDA-Based ModelArticle Published on 2022-10-142022-11-16 Journal: International Journal of Environmental Research an [Category] 변종, [키워드] affective Analysis BERT boost build change Clustering coronavirus variant country COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Data analysis early stage effective intervention Effectiveness Evidence Evolution explicit FDA functional functional data analysis Government greater groups Health machine learning model media Model opinion outbreak predict Public second sentiment analysis Side effects Spread the vaccine Topic topic model. vaccination rates Vaccine vaccine-hesitant while [DOI] 10.3390/ijerph192013248 PMC 바로가기
Global-scale modeling of early factors and country-specific trajectories of COVID-19 incidence: a cross-sectional study of the first 6 months of the pandemicObservational Study Published on 2022-10-142023-07-10 Journal: BMC Public Health [Category] COVID19(2023년), [키워드] Clustering COVID-19 Factors Global lockdown modeling Regression. [DOI] 10.1186/s12889-022-14336-w PMC 바로가기 [Article Type] Observational Study
Real-Time Analysis of Predictors of COVID-19 Infection Spread in Countries in the European Union Through a New ToolArticle Published on 2022-10-062022-11-16 Journal: International Journal of Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] age center Characteristics Clustering comparative analyses Continuous data Control correlation country COVID-19 COVID-19 case COVID-19 cases COVID-19 infection COVID-19 non-pharmaceutical interventions COVID-19 prediction COVID-19 virus COVID-19 Virus variants Data analysis distribution Effect European Expenditure healthcare Hierarchical Impact Including Infection interactive visualization Intervention Johns Hopkins University machine learning machine learning model measure Measures New pandemic predict predictor predictors prevention random Social epidemiology Spread Support survey time series cross-validation. trend union vaccination [DOI] 10.3389/ijph.2022.1604974 PMC 바로가기
Guiding the design of SARS-CoV-2 genomic surveillance by estimating the resolution of outbreak detectionArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] approach Cluster Clustering delta variant detect Epidemiology Genetic genomic Genomic surveillance Guiding incidence index case Infection less measure MONITOR New new virus outbreak outbreak detection Outbreaks pathogen pathogen genomics proportion public health public health. recommendation reduced resources SARS-CoV-2 SARS-CoV-2 genomic surveillance sequence sequenced Sequencing similarity South Surveillance the SARS-CoV-2 variants whole genome [DOI] 10.3389/fpubh.2022.1004201 PMC 바로가기
Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West AfricaArticle Published on 2022-10-032022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ABO ABO blood grouping ABO blood groups acute respiratory syndrome African anti-SARS-CoV-2 antibody antibodies antibody association Asymptomatic Asymptomatic case Blood Blood Group Clustering comparison Concentration coronavirus coronavirus disease correlations COVID-19 COVID-19 severity cytokine cytokine level decrease discrepancy disease severity Eotaxin Factor genetic background group groups Host identify IL-6 IL-8 immune marker Immune profile immune response individuals Kruskal-Wallis Mann-Whitney U test Mild Multiple Multiplex assay offer participant PCR-confirmed performed phenotype plasma Probing proportion quantification recorded reduced regression analysis significantly Spearman statistically significant symptomatic symptomatic and asymptomatic symptomatic patient tested two-tailed was performed was used West West Africa. [DOI] 10.1186/s12916-022-02571-2 PMC 바로가기
A dual-stage deep convolutional neural network for automatic diagnosis of COVID-19 and pneumonia from chest CT imagesResearch article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, 진단, 치료기술, [키워드] Accuracy agglomerative hierarchical clustering automated Chest CT image chest CT scan classification Clustering CNN Computed tomography Convolutional neural network COVID-19 deep learning diagnosing Diagnosis diagnosis of COVID-19 diagnostic effective information introduced lung overcome pandemic patients Pneumonia provide Region required Segmentation Significant traditional methods [DOI] 10.1016/j.compbiomed.2022.105806 [Article Type] Research article
An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)Article Published on 2022-09-302022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis binding Clustering co-evolution Computational drug conformational flexibility Conventional COVID-19 Critical deep Deep mutation scan develop drug-target druggability Effect Evolution expected exploratory feature Fuzzy C-means clustering highlight impair Interaction machine machine learning molecular dynamic simulation Molecular simulation Mutation network analysis Protein Quantitative RBD Receptor binding domain Region SARS-CoV-2 sequence Sequence space analysis small molecule stability Structure Structure network analysis. the RBD the SARS-CoV-2 turn [DOI] 10.1016/j.ijbiomac.2022.07.022 PMC 바로가기